Review Article

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TOMOGRAPHY, March 2016, Volume 2, Issue 1: 3-16
DOI: 10.18383/j.tom.2016.00121

Radioactive Nanomaterials for Multimodality Imaging

Daiqin Chen1,2, Casey A. Dougherty1,2, Dongzhi Yang1,2, Hongwei Wu1,2, and Hao Hong1,2,3

1Department of Radiology, University of Michigan, Ann Arbor, Michigan; 2Center for Molecular Imaging, University of Michigan, Ann Arbor, Michigan; and 3Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan

Abstract

Nuclear imaging techniques, primarily including positron emission tomography and single-photon emission computed tomography, can provide quantitative information for a biological event in vivo with ultrahigh sensitivity; however, the comparatively low spatial resolution is their major limitation in clinical application. With the convergence of nuclear imaging with other imaging modalities like computed tomography, magnetic resonance imaging, and optical imaging, the hybrid imaging platforms can overcome the limitations of each individual imaging technique. Possessing versatile chemical linking ability and good cargo-loading capacity, radioactive nanomaterials can serve as ideal imaging contrast agents. Here, we provide a brief overview about the current state-of-the-art applications of radioactive nanomaterials in multimodality imaging. We present strategies for incorporation of radioisotope(s) into nanomaterials with the applications of radioactive nanomaterials in multimodal imaging. Advantages and limitations of radioactive nanomaterials for multimodal imaging applications are discussed. Finally, a future perspective of possible radioactive nanomaterial utilization is presented for improving diagnosis and patient management in a variety of diseases.

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