Research Articles

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TOMOGRAPHY, March 2018, Volume 4, Issue 1:4-13
DOI: 10.18383/j.tom.2017.00021

Assessing Mucosal Inflammation in a DSS-Induced Colitis Mouse Model by MR Colonography

Inbal E. Biton1, Noa Stettner1, Ori Brener1, Ayelet Erez2, Alon Harmelin1, Joel R. Garbow4

1Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel;2Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel;3Koret School of Veterinary Medicine, Hebrew University, Rehovot, Israel; and4Biomedical Magnetic Resonance Laboratory, Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO

Abstract

Inflammatory bowel disease (IBD) is characterized by a chronic flaring inflammation of the gastrointestinal tract. To determine disease activity, the inflammatory state of the colon should be assessed. Endoscopy in patients with IBD aids visualization of mucosal inflammation. However, because the mucosa is fragile, there is a significant risk of perforation. In addition, the technique is based on grading of the entire colon, which is highly operator-dependent. An improved, noninvasive, objective magnetic resonance imaging (MRI) technique will effectively assess pathologies in the small intestinal mucosa, more specifically, along the colon, and the bowel wall and surrounding structures. Here, dextran sodium sulfate polymer induced acute colitis in mice that was subsequently characterized by multisection magnetic resonance colonography. This study aimed to develop a noninvasive, objective, quantitative MRI technique for detecting mucosal inflammation in a dextran sodium sulfate–induced colitis mouse model. MRI results were correlated with endoscopic and histopathological evaluations.

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