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TOMOGRAPHY, June 2018, Volume 4, Issue 2:78-83
DOI: 10.18383/j.tom.2018.00008

Manganese-Enhanced Magnetic Resonance Imaging for Detection and Characterization of Colorectal Cancers

Liang Wen1, Xinan Shi2, Liping He3, Dan Han1

1The First Affiliated Hospital of Kunming Medical University, Kunming, China;2Chinese Medicine College of Yun Nan, Kunming, Chinac; and3Public Health School of Kunming Medical University, Kunming, China

Abstract

Here, we investigated the diagnostic performance of manganese (Mn)-enhanced magnetic resonance imaging (MEMRI) in colorectal cancer (CRC). The ability of CRC cell lines SW620 and SW480 to uptake Mn was evaluated and compared with a normal colon cell using MEMRI. Subcutaneous xenografts in nude mice underwent MRI examination at tumor sizes of 5, 10, and 15 mm. Contrast enhancement was compared between gadolinium (Gd)- and Mn-enhanced MRI. SW620 and SW480 cell lines took up more Mn2+ than normal cells, resulting in 4.5 and 2 times greater T1 value shortening than normal cell using in vitro MEMRI (P < .001). Most xenografts (17/23) enhanced markedly on MEMRI. A heterogeneous enhancement pattern invariably noted whether Mn or Gd agents were administered, but tumors imaged using MEMRI showed a greater degree of enhancement with a larger extent of enhanced area than those imaged using Gd-enhanced MRI. The numbers of markedly Mn-enhanced cases were more in the 5-mm-size tumor group than in 10- or 15-mm-size tumor groups. Overall, MEMRI could enhance CRCs and it showed potential in detecting early small lesions and markedly enhancing tumors that had minimal Gd enhancement.

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