Image Report

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TOMOGRAPHY, December 2015, Volume 1, Issue 2: 81-84
DOI: 10.18383/j.tom.2015.00169

Uptake of [18F]DCFPyL in Paget’s Disease of Bone, an Important Potential Pitfall in the Clinical Interpretation of PSMA PET Studies

Steven P. Rowe1, Curtiland Deville2, Channing Paller3, Steve Y. Cho5, Elliot K. Fishman1, Martin G. Pomper1,3, Ashley E. Ross4, and Michael A. Gorin4

1Russell H. Morgan Department of Radiology and Radiological Science, 2Department of Radiation Oncology and Molecular Radiation Sciences, 3Sidney Kimmel Comprehensive Cancer Center, and 4The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD; and 5Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA


Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) imaging is an emerging technique for evaluating patients with prostate cancer (PCa) in a variety of clinical contexts. As with any new imaging modality, there are interpretive pitfalls that are beginning to be recognized. In this report, we describe the findings in a 63-year-old male with biochemically recurrent PCa after radical prosta- tectomy who was imaged with 2-(3-{1-carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)- pentanedioic acid ([18F]DCFPyL), a small-molecule inhibitor of PSMA. Diffuse radiotracer uptake was noted throughout the sacrum, corresponding to imaging findings on contrast-enhanced computed tomography (CT), bone scan, and pelvic magnetic resonance imaging consistent with Paget’s disease of bone. The uptake of [18F]DCFPyL in Paget’s disease most likely results from hyperemia and increased radiotracer delivery. In light of the overlap in patients affected by PCa and Paget’s disease, it is important for nuclear medicine physi- cians and radiologists to be aware of the potential for this diagnostic pitfall when interpreting PSMA PET/CT scans. Correlating findings on conventional imaging such as diagnostic CT and bone scan can help confirm the diagnosis.


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