Research Articles

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TOMOGRAPHY, December 2015, Volume 1, Issue 2: 136-144
DOI: 10.18383/j.tom.2015.00166

Simultaneous T1 and T2 Brain Relaxometry in Asymptomatic Volunteers Using Magnetic Resonance Fingerprinting

Chaitra Badve1, Alice Yu2, Matthew Rogers2, Dan Ma3, Yiying Liu4, Mark Schluchter4, Jeffrey Sunshine1, Mark Griswold1,3, and Vikas Gulani1,3

1Department of Radiology, Case Western Reserve University and University Hospitals, Cleveland, OH and 2School of Medicine, Case Western Reserve University, Cleveland, OH, USA; 3Department of Biomedical Engineering, Case Western Reserve University and University Hospitals, Cleveland, OH, USA and 4Department of Biostatistics and Bioinformatics Core, Case Western Reserve University and University Hospitals, Cleveland, OH, USA


Magnetic resonance fingerprinting (MRF) is an imaging tool that produces multiple magnetic resonance imaging parametric maps from a single scan. Herein we describe the normal range and progression of MRF-derived relaxometry values with age in healthy individuals. In total, 56 normal volunteers (24 men and 32 women) aged 11-71 years were scanned. Regions of interest were drawn on T1 and T2 maps in 38 areas, including lobar and deep white matter (WM), deep gray nuclei, thalami, and posterior fossa structures. Relaxometry differences were assessed using a forward stepwise selection of a baseline model that included either sex, age, or both, where variables were included if they contributed significantly (P < .05). In addition, differences in regional anatomy, including comparisons between hemispheres and between anatomical subcomponents, were assessed by paired t tests. MRF-derived T1 and T2 in frontal WM regions increased with age, whereas occipital and temporal regions remained relatively stable. Deep gray nuclei such as substantia nigra, were found to have age-related decreases in relaxometry. Differences in sex were observed in T1 and T2 of temporal regions, the cerebellum, and pons. Men were found to have more rapid age-related changes in frontal and parietal WM. Regional differences were identified between hemispheres, between the genu and splenium of the corpus callosum, and between posteromedial and anterolateral thalami. In conclusion, MRF quantification measures relaxometry trends in healthy individuals that are in agreement with the current understanding of neurobiology and has the ability to uncover additional patterns that have not yet been explored.


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