Research Articles

Download PDF (690.07 KB)

TOMOGRAPHY, December 2016, Volume 2, Issue 4: 308-316
DOI: 10.18383/j.tom.2016.00202

Evaluation of Soft-Tissue Sarcoma Response to Preoperative Chemoradiotherapy Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Wei Huang1,2, Brooke R. Beckett3, Alina Tudorica3, Janelle M. Meyer4, Aneela Afzal1, Yiyi Chen2,5, Atiya Mansoor6, James B. Hayden7, Yee-Cheen Doung7, Arthur Y. Hung8, Megan L. Holtorf, Torrie J. Aston, and Christopher W. Ryan

1Advanced Imaging Research Center, 2Knight Cancer Institute, 3Department of Diagnostic Radiology, 4Division of Hematology and Medical Oncology, 5Department of Public Health and Preventive Medicine, 6Department of Pathology, 7Department of Orthopaedics and Rehabilitation, and 8Department of Radiation Medicine, Oregon Health & Science University, Portland, Oregon


This study aims to assess the utility of quantitative dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters in comparison with imaging tumor size for early prediction and evaluation of soft tissue sarcoma response to preoperative chemoradiotherapy. In total, 20 patients with intermediate- to high-grade soft tissue sarcomas received either a phase I trial regimen of sorafenib + chemoradiotherapy (n = 8) or chemoradiotherapy only (n = 12), and underwent DCE-MRI at baseline, after 2 weeks of treatment with sorafenib or after the first chemotherapy cycle, and after therapy completion. MRI tumor size in the longest diameter (LD) was measured according to the RECIST (Response Evaluation Criteria In Solid Tumors) guidelines. Pharmacokinetic analyses of DCE-MRI data were performed using the Shutter-Speed model. After only 2 weeks of treatment with sorafenib or after 1 chemotherapy cycle, Ktrans (rate constant for plasma/interstitium contrast agent transfer) and its percent change were good early predictors of optimal versus suboptimal pathological response with univariate logistic regression C statistics values of 0.90 and 0.80, respectively, whereas RECIST LD percent change was only a fair predictor (C = 0.72). Post-therapy Ktrans, ve (extravascular and extracellular volume fraction), and kep (intravasation rate constant), not RECIST LD, were excellent (C > 0.90) markers of therapy response. Several DCE-MRI parameters before, during, and after therapy showed significant (P < .05) correlations with percent necrosis of resected tumor specimens. In conclusion, absolute values and percent changes of quantitative DCE-MRI parameters provide better early prediction and evaluation of the pathological response of soft tissue sarcoma to preoperative chemoradiotherapy than the conventional measurement of imaging tumor size change.


Download the article PDF (690.07 KB)

Download the full issue PDF (200.5 MB)

Mobile-ready Flipbook

View the full issue as a flipbook (Desktop and Mobile-ready)