Research Articles

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TOMOGRAPHY, December 2016, Volume 2, Issue 4: 374-377
DOI: 10.18383/j.tom.2016.00244

An Approach Toward Automatic Classification of Tumor Histopathology of Non–Small Cell Lung Cancer Based on Radiomic Features

Ravindra Patil1, Geetha Mahadevaiah1, and Andre Dekker2

1Philips Research India, Bangalore, India and 2Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre (MUMC), Maastricht University, Maastricht, The Netherlands

Abstract

Non–small cell lung cancer contributes toward 85% of all lung cancer burden. Tumor histology (squamous cell carcinoma, large cell carcinoma, and adenocarcinoma and "not otherwise specified") has prognostic significance, and it is therefore imperative to identify tumor histology for personalized medicine; however, biopsies are not always possible and carry significant risk of complications. Here, we have used Radiomics, which provides an exhaustive number of informative features, to aid in diagnosis and therapeutic outcome of tumor characteristics in a noninvasive manner. This study evaluated radiomic features of non–small cell lung cancer to identify tumor histopathology. We included 317 subjects and classified the underlying tumor histopathology into its 4 main subtypes. The performance of the current approach was determined to be 20% more accurate than that of an approach considering only the volumetric- and shape-based features.

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